http://hdl.handle.net/10451/3093 2013-05-22T04:01:50Z 2013-05-22T04:01:50Z Glória, Paulo M C Gut, Jiri Gonçalves, Lídia M Rosenthal, Philip J Moreira, Rui Santos, Maria M M http://hdl.handle.net/10451/8155 2013-04-02T13:59:25Z 2011-01-01T00:00:00Z

Title: Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents Authors: Glória, Paulo M C; Gut, Jiri; Gonçalves, Lídia M; Rosenthal, Philip J; Moreira, Rui; Santos, Maria M M Abstract: A series of novel aza vinyl sulfones were designed, synthesized in good yields and evaluated as antiplasmodial agents. Tested compounds did not show activity against papain or the Plasmodium falciparum cysteine protease falcipain-2. However, a number of the new compounds effectively inhibited the in vitro development of P. falciparum. Compounds containing a squaramide group were the most active, with IC50 values between 0.95 and 4.5 μM, suggesting that these are potential lead compounds for the development of new antimalarial agents.

2011-01-01T00:00:00Z Ribeiro, Carlos J A Kumar, S Praveen Moreira, Rui Santos, Maria M M http://hdl.handle.net/10451/8154 2013-04-02T13:51:01Z 2012-01-01T00:00:00Z

Title: Efficient synthesis of spiroisoxazoline oxindoles Authors: Ribeiro, Carlos J A; Kumar, S Praveen; Moreira, Rui; Santos, Maria M M Abstract: The synthesis of spiroisoxazoline oxindoles containing ester groups at position 4′ and aromatic or ester groups at position 3′ of the isoxazoline ring is reported. The compounds were synthesized in yields up to 94% by 1,3-dipolar cycloaddition of 3-methylene indolin-2-ones and chlorooximes in the presence of triethylamine or zinc. Description: Acknowledgments: We thank Fundação para a Ciência e Tecnologia (Portugal) for financial support [Projects PTDC/QUI-QUI/111664/2009 and PTDC/SAU-FAR/110848/2009 and Fellowships SFRH/BD/69258/2010 and SFRH/BPD/44481/2008].

2012-01-01T00:00:00Z Bettencourt, A Neves, C. B. Almeida, M. S. de Pinheiro, L. M. Oliveira, S. A. Lopes, L. P. Castro, M. F. http://hdl.handle.net/10451/8043 2013-03-22T14:33:00Z 2010-01-01T00:00:00Z

Title: Biodegradation of acrylic based resins: A review Authors: Bettencourt, A; Neves, C. B.; Almeida, M. S. de; Pinheiro, L. M.; Oliveira, S. A.; Lopes, L. P.; Castro, M. F. Abstract: Objectives. The development of different types of materials with application in dentistry is an area of intense growth and research, due to its importance in oral health. Among the different materials there are the acrylic based resins that have been extensively used either in restorations or in dentures. The objective of this manuscript was to review the acrylic based resins biodegradation phenomena. Specific attention was given to the causes and consequences of materials degradation under the oral environment. Data and sources. Information from scientific full papers, reviews or abstracts published from 1963 to datewere included in the review. Published materialwas searched in dental literature using general and specialist databases, like the PubMED database. Study selection. Published studies regarding the description of biodegradation mechanisms, in vitro and in vivo release experiments and cell based studies conducted on acrylic based resins or their components were evaluated. Studies related to the effect of biodegradation on the physical and mechanical properties of the materials were also analyzed. Conclusions. Different factors such as saliva characteristics, chewing or thermal and chemical dietary changes may be responsible for the biodegradation of acrylic based resins. Release of potential toxic compounds from the material and change on their physical and mechanical properties are the major consequences of biodegradation. Increasing concern arises from potential toxic effects of biodegradation products under clinical application thus justifying an intensive research in this area.

2010-01-01T00:00:00Z Salgueiro, Pedro Dias, Catarina Carreiras, M. Carmo Borges, Carlos http://hdl.handle.net/10451/7627 2013-02-01T12:10:28Z 2007-11-01T00:00:00Z

Title: Electron Ionization Mass Spectrometric Study of Some Substituted 1,3-oxazoles Authors: Salgueiro, Pedro; Dias, Catarina; Carreiras, M. Carmo; Borges, Carlos Abstract: Heterocyclic compounds are widely used as pharmaceuticals. Tacrine (THA) was the first drug approved for the treatment of Alzheimer’s disease (AD) and a great effort has been made to design and synthesize new THA-analogues in order to evaluate their beneficial effects as therapeutic agents in this disease.1-6 Contrasting with the pharmaceutical interest, mass spectrometric studies of these compounds and of some of its precursors, namely the oxazole and oxazole derivatives, are scarce. In order to obtain its structural information, a mass spectrometric study was performed with some 5-amino-2-aryl-4-cyano-1,3-oxazoles (Compounds 1 - 5) using a quadrupole mass spectrometer, equipped with an electron ionization (EI) ion source. Detailed fragmentation pathways have been established for all significant ions, including some fragment ions characteristic of the oxazole family. 1. Marco JL, Ríos C, Carreiras MC, Baños JE, Badía A, Vivas NM. Bioorg. Med. Chem. 2001; 9: 727. 2. Ros E, Aleu J, Gomez de Aranda I, Canti C, Pang YP, Marsal J, Solsona C. J Neurophysiol. 2001; 86: 183. 3. Marco JL, Ríos C, Carreiras MC, Baños JE, Badía A, Vivas NM. Arch. Pharm. Pharm. Med. Chem. 2002; 7: 347. 4. Barreiro EJ, Câmara CA, Verli H, Brazilmás L, Castro NG, Cintra WM, Aracava Y, Rodrigues CR, Fraga CAM. Journal of Medicinal Chemistry 2003; 46: 1144. 5. Marco JL, Carreiras MC. Mini-Rev. Med. Chem. 2003; 3: 518. 6. Marco JL, Ríos C, García AG, Villarroya M, Carreiras MC, Martins C, Eleutério A, Morreale A, Orozco M, Luque FJ. Bioorg. Med. Chem. 2004; 12: 2199. Description: Comunicação oral sob a forma painel

2007-11-01T00:00:00Z