http://hdl.handle.net/10451/3521 Fri, 24 May 2013 20:27:08 GMT 2013-05-24T20:27:08Z http://hdl.handle.net/10451/8155 Title: Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents Authors: Glória, Paulo M C; Gut, Jiri; Gonçalves, Lídia M; Rosenthal, Philip J; Moreira, Rui; Santos, Maria M M Abstract: A series of novel aza vinyl sulfones were designed, synthesized in good yields and evaluated as antiplasmodial agents. Tested compounds did not show activity against papain or the Plasmodium falciparum cysteine protease falcipain-2. However, a number of the new compounds effectively inhibited the in vitro development of P. falciparum. Compounds containing a squaramide group were the most active, with IC50 values between 0.95 and 4.5 μM, suggesting that these are potential lead compounds for the development of new antimalarial agents. Sat, 01 Jan 2011 00:00:00 GMT http://hdl.handle.net/10451/8155 2011-01-01T00:00:00Z http://hdl.handle.net/10451/8154 Title: Efficient synthesis of spiroisoxazoline oxindoles Authors: Ribeiro, Carlos J A; Kumar, S Praveen; Moreira, Rui; Santos, Maria M M Abstract: The synthesis of spiroisoxazoline oxindoles containing ester groups at position 4′ and aromatic or ester groups at position 3′ of the isoxazoline ring is reported. The compounds were synthesized in yields up to 94% by 1,3-dipolar cycloaddition of 3-methylene indolin-2-ones and chlorooximes in the presence of triethylamine or zinc. Description: Acknowledgments: We thank Fundação para a Ciência e Tecnologia (Portugal) for financial support [Projects PTDC/QUI-QUI/111664/2009 and PTDC/SAU-FAR/110848/2009 and Fellowships SFRH/BD/69258/2010 and SFRH/BPD/44481/2008]. Sun, 01 Jan 2012 00:00:00 GMT http://hdl.handle.net/10451/8154 2012-01-01T00:00:00Z http://hdl.handle.net/10451/8043 Title: Biodegradation of acrylic based resins: A review Authors: Bettencourt, A; Neves, C. B.; Almeida, M. S. de; Pinheiro, L. M.; Oliveira, S. A.; Lopes, L. P.; Castro, M. F. Abstract: Objectives. The development of different types of materials with application in dentistry is an area of intense growth and research, due to its importance in oral health. Among the different materials there are the acrylic based resins that have been extensively used either in restorations or in dentures. The objective of this manuscript was to review the acrylic based resins biodegradation phenomena. Specific attention was given to the causes and consequences of materials degradation under the oral environment. Data and sources. Information from scientific full papers, reviews or abstracts published from 1963 to datewere included in the review. Published materialwas searched in dental literature using general and specialist databases, like the PubMED database. Study selection. Published studies regarding the description of biodegradation mechanisms, in vitro and in vivo release experiments and cell based studies conducted on acrylic based resins or their components were evaluated. Studies related to the effect of biodegradation on the physical and mechanical properties of the materials were also analyzed. Conclusions. Different factors such as saliva characteristics, chewing or thermal and chemical dietary changes may be responsible for the biodegradation of acrylic based resins. Release of potential toxic compounds from the material and change on their physical and mechanical properties are the major consequences of biodegradation. Increasing concern arises from potential toxic effects of biodegradation products under clinical application thus justifying an intensive research in this area. Fri, 01 Jan 2010 00:00:00 GMT http://hdl.handle.net/10451/8043 2010-01-01T00:00:00Z http://hdl.handle.net/10451/3937 Title: Two new diterpenoids from Plectranthus species Authors: Simões, M. Fátima; Rijo, Patrícia; Duarte, Aida; Barbosa, Diana; Matias, Diogo; Delgado, Joana; Cirilo, Nádia; Rodríguez, Benjamín Abstract: Two new diterpenoids, ent-7α-acetoxy-15-beyeren-18-oic acid and (13S,15S)-6β,7α,12α,19-tetrahydroxy-13β,16-cyclo-8-abietene-11,14-dione, have been isolated from Plectranthus saccatus and Plectranthus porcatus, respectively, and their structures were established by 1D and 2D NMR spectroscopic studies. The new diterpenes showed no activity against Gram-negative bacteria and Candida albicans (yeast strain). Among Gram-positive bacteria, the lower MIC value was 62.50 μg/ml for the abietane derivative against Staphylococcus aureus ATCC 6538. Fri, 01 Jan 2010 00:00:00 GMT http://hdl.handle.net/10451/3937 2010-01-01T00:00:00Z