Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/10685
Título: Behaviour of human erythrocyte aggregation in presence of autologous lipoproteins
Autor: Saldanha, C.
Loureiro, J.
Moreira, C.
Martins e Silva, J.
Data: 2012
Editora: Hindawi Publishing Corporation
Citação: Biochemistry Research International, Volume 2012, Article ID 261736, 6 pages
Resumo: The aim of this work was to evaluate in vitro the effect of autologous plasma lipoprotein subfractions on erythrocyte tendency to aggregate. Aliquots of human blood samples were enriched or not (control) with their own HDL-C, LDL-C, or VLDL-C fractions obtained from the same batch by density gradient ultracentrifugation. Plasma osmolality and erythrocyte aggregation index (EAI) were determined. Blood aliquots enriched with LDL-C and HDL-C showed significant higher EAI than untreated aliquots, whereas enrichment with VLDL-C does not induce significant EAI changes. For the same range of lipoprotein concentrations expressed as percentage of osmolality variation, the EAI variation was positive and higher in presence of HDL-C than upon enrichment with LDL-C (P < 0.01). Particle size, up to LDL diameter values, seems to reinforce erythrocyte tendency to aggregate at the same plasma osmolality (particle number) range of values.
Descrição: Copyright © 2012 C. Saldanha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Peer review: yes
URI: http://dx.doi.org/10.1155/2012/261736
ISSN: 2090-2247
Aparece nas colecções:IMM - Artigos em Revistas Internacionais

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