Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/11512
Título: The European COPHES/DEMOCOPHES project: towards transnational comparability and reliability of human biomonitoring results
Autor: Schindler, Birgit Karin
Esteban, Marta
Koch, Holger Martin
Castano, Argelia
Koslitz, Stephan
Cañas, Ana
Casteleyn, Ludwine
Kolossa-Gehring, Marike
Schwedler, Gerda
Schoeters, Greet
Hond, Elly Den
Sepai, Ovnair
Exley, Karen
Bloemen, Louis
Horvat, Milena
Knudsen, Lisbeth E.
Joas, Anke
Joas, Reinhard
Biot, Pierre
Aerts, Dominique
Lopez, Ana
Huetos, Olga
Katsonouri, Andromachi
Maurer-Chronakis, Katja
Kasparova, Lucie
Vrbík, Karel
Rudnai, Peter
Naray, Miklos
Guignard, Cedric
Fischer, Marc E.
Ligocka, Danuta
Janasik, Beata
Reis, M. Fátima
Namorado, Sónia
Pop, Cristian
Dumitrascu, Irina
Halzlova, Katarina
Fabianova, Eleonora
Mazej, Darja
Tratnik, Janja Snoj
Berglund, Marika
Jönsson, Bo
Lehmann, Andrea
Crettaz, Pierre
Frederiksen, Hanne
Nielsen, Flemming
McGrath, Helena
Nesbitt, Ian
Cremer, Koen De
Vanermen, Guido
Koppen, Gudrun
Wilhelm, Michael
Becker, Kerstin
Angerer, Jürgen
Palavras-chave: COPHES
Quality assurance
Data: 2014
Editora: Elsevier
Citação: International Journal of Hygiene and Environmental Health 217 (2014) 653–661
Resumo: COPHES/DEMOCOPHES has its origins in the European Environment and Health Action Plan of 2004 to “develop a coherent approach on human biomonitoring (HBM) in Europe”. Within this twin-project it was targeted to collect specimens from 120 mother–child-pairs in each of the 17 participating Europeancountries. These specimens were investigated for six biomarkers (mercury in hair; creatinine, cotinine,cadmium, phthalate metabolites and bisphenol A in urine). The results for mercury in hair are described in a separate paper. Each participating member state was requested to contract laboratories, for capacity building reasons ideally within its borders, carrying out the chemical analyses. To ensure comparability of analytical data a Quality Assurance Unit (QAU) was established which provided the participating laboratories with standard operating procedures (SOP) and with control material. This material was specially prepared from native, non-spiked, pooled urine samples and was tested for homogeneity and stability.Four external quality assessment exercises were carried out. Highly esteemed laboratories from all over the world served as reference laboratories. Web conferences after each external quality assessment exercise functioned as a new and effective tool to improve analytical performance, to build capacity and to educate less experienced laboratories. Of the 38 laboratories participating in the quality assurance exercises 14 laboratories qualified for cadmium, 14 for creatinine, 9 for cotinine, 7 for phthalate metabolitesand 5 for bisphenol A in urine. In the last of the four external quality assessment exercises the laboratories that qualified for DEMOCOPHES performed the determinations in urine with relative standard deviations(low/high concentration) of 18.0/2.1% for cotinine, 14.8/5.1% for cadmium, 4.7/3.4% for creatinine. Relative standard deviations for the newly emerging biomarkers were higher, with values between 13.5 and 20.5% for bisphenol A and between 18.9 and 45.3% for the phthalate metabolites. Plausibility control of the HBM results of all participating countries disclosed analytical shortcomings in the determination of Cd when using certain ICP/MS methods. Results were corrected by reanalyzes. The COPHES/DEMOCOPHESproject for the first time succeeded in performing a harmonized pan-European HBM project. All data raised have to be regarded as utmost reliable according to the highest international state of the art, since highly renowned laboratories functioned as reference laboratories. The procedure described here, that has shown its success, can be used as a blueprint for future transnational, multicentre HBM projects.
Descrição: © 2013 Elsevier GmbH. All rights reserved.
Peer review: yes
URI: http://dx.doi.org/10.1016/j.ijheh.2013.12.002
ISSN: 1438-4639
Versão do Editor: The definitive version is available at http://www.elsevier.com
Aparece nas colecções:FM-IMPSP-Artigos em Revistas Internacionais

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