Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/11747
Título: Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but requires early T-cell receptor expression
Autor: Nunes-Cabaço, H.
C Ribot, Julie
Caramalho, Íris
Serra-Caetano, Ana
Silva-Santos, Bruno
E Sousa, Ana
Palavras-chave: Foxp3
Human T-cell development
Murine T-cell development
Regulatory T cells
Data: 2010
Editora: Nature Publishing Group
Citação: Immunology and Cell Biology (2010), 1–6
Resumo: The thymus generates a T-cell lineage dedicated to immune regulation, 'naturally occurring' regulatory T cells, best specified by the forkhead family transcription factor Foxp3. Here, we have conducted a parallel study in humans and mice where we have dissected the earliest stages of Foxp3 induction during thymocyte development. By analyzing a large collection of 21 human thymuses we show that Foxp3 can be consistently detected in CD4 immature single positive thymocytes that precede the CD4(+)CD8(+) (double positive, DP) stage. The reduced levels of CD3 expression found at this stage of human thymocyte development raise the question of TCR (T-cell receptor) requirement for Foxp3 induction. We further show that, in mice, Foxp3 expression was also detected in pre-DP thymocytes of TCRalpha-sufficient but not in TCRalpha-deficient animals, genetically showing the TCR dependence of Foxp3 expression at pre-DP stages of T-cell development.
Descrição: © 2010 Australasian Society for Immunology Inc. All rights reserved
Peer review: yes
URI: http://dx.doi.org/10.1038/icb.2010.4
ISSN: 0818-9641
Aparece nas colecções:IMM - Artigos em Revistas Internacionais
FM-LIC - Artigos em Revistas Internacionais

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