Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/15880
Título: Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection.
Autor: Soares, R.
Foxall, R.
Albuquerque, A.
Cortesão, C.
Garcia, M.
Victorino, R. M.
Sousa, A. E.
Data: 2006
Editora: American Society for Microbiology
Citação: Journal of Virology, Dec. 2006, Vol. 80, No. 24, p. 12425–12429
Resumo: CCR5 expression determines susceptibility to infection, cell tropism, and the rate of human immunodeficiency virus type 1 (HIV-1) disease progression. CCR5 is also considered the major HIV-2 coreceptor in vivo, in spite of broad coreceptor use in vitro. Here we report a significantly increased proportion of memory-effector CD4 T cells expressing CCR5 in HIV-2-infected patients correlating with CD4 depletion. Moreover, HIV-2 proviral DNA was essentially restricted to memory-effector CD4, suggesting that this is the main target for HIV-2. Similar levels of proviral DNA were found in the two infection categories. Thus, the reduced viremia and slow rate of CD4 decline that characterize HIV-2 infection seem to be unrelated to coreceptor availability.
Descrição: © 2006, American Society for Microbiology. All Rights Reserved.
Peer review: yes
URI: http://dx.doi.org/ 10.1128/JVI.01557-06
ISSN: 0022-538X
Versão do Editor: The definitive version is available at http://jvi.asm.org/
Aparece nas colecções:IMM - Artigos em Revistas Internacionais
FM-LIC - Artigos em Revistas Internacionais

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