Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/15882
Título: Kinetics of the changes of lymphocyte subsets defined by cytokine production at single cell level
Autor: Sousa, A. E.
Chaves, A. F.
Doroana, M.
Antunes, F.
Victorino, R. M.
Data: 1999
Editora: American Association of Immunologists
Citação: J Immunol 1999; 162:3718-3726
Resumo: The effects of highly active antiretroviral therapy on cytokine imbalances associated with HIV-1 infection have not been characterized. Using single cell analysis by flow cytometry, we show that a significant recovery in the frequency of IL-2-producing cells was only observed in patients with a sustained control of viral replication and that the overexpanded CD8 T cell population of CD282 IFN-g1 cells was not significantly reduced after 1 yr of effective therapy. Moreover, a detrimental role of IL-4 is suggested by the association between an enhanced proportion of IL-4-producing cells within the CD4 and particularly the CD8 subset and viral load rebound. Finally, the kinetics of changes of cell subsets assessed for simultaneous production of different cytokines supports the view that cell reconstitution during highly active antiretroviral therapy is initially due to redistribution of terminally differentiated cells, followed by peripheral expansion of less differentiated ones and a late progressive increase of the proportion of functionally defined naive/memory precursor lymphocytes. These data bring new support for the role of cytokine imbalances in AIDS pathogenesis and may be relevant for the definition of immunointervention targets.
Descrição: © 1999 by The American Association of Immunologists All rights reserved.
Peer review: yes
URI: http://www.jimmunol.org/content/162/6/3718.abstract
ISSN: 0022-1767
Versão do Editor: The definitive version is available at http://www.jimmunol.org/
Aparece nas colecções:IMM - Artigos em Revistas Internacionais
FM-LIC - Artigos em Revistas Internacionais

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