Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/17736
Título: Personality, manual preference and neuroendocrine reactivity in hirsute subjects
Autor: Martin Martins, J.
Vale, S. do
Trinca, A.
Saldanha, C.
Martins e Silva, J.
Palavras-chave: Hyperandrogenism
Personality profile
Manual preference
Pituitary–adrenal axis reactivity
Data: 2004
Editora: Elsevier
Citação: Physiology & Behavior 82 (2004) 741–749
Resumo: Behavioral and neuroendocrine differences may be postulated in hirsute subjects since central effects of gonadal steroids are well established. We conducted a controlled clinical study with 25 consecutive young hirsute participants compared with 20 consecutive controls. Neuropsychological evaluation included the Minnesota Multiphasic Personality Inventory (MMPI) and the Edinburgh Inventory of Manual Preference (EIMP). Neuroendocrine reactivity was assessed by the adrenocorticotropic hormone (ACTH) and cortisol responses to corticotropin releasing hormone (CRH). Hirsute participants presented a flattened personality profile with lower neurotic triad scores—146±20 versus 166±28. Left-hand preference was more common in hirsute participants—4/21 versus 0/20. Decreased ACTH [area under the curve (AUC)—36±28 vs. 72±63 pg/ml h] and cortisol (AUC—18±4 vs. 25±10 Ag/dl h) responses to CRH were found in the hirsute group. In the hirsute group, higher manual preference scores were associated with lower ACTH responses to CRH, while the opposite association was found in the control group. In the hirsute group, the hyporeactive hypothalamic–pituitary–adrenal (HPA) axis was associated with lower behavior-deviant scores, while in the control group, the hyporeactive HPA axis was associated with more psychopathology. We conclude that personality and HPA axis reactivity are different in hirsute female participants when compared with controls, with a trend for differences regarding handedness. Personality and handedness are differently associated with HPA reactivity. Distinctive features in hirsute participants are probably established very early during ontogenic development.
Descrição: © 2004 Elsevier Inc. All rights reserved.
Peer review: yes
URI: http://dx.doi.org/10.1016/j.physbeh.2004.06.015
http://hdl.handle.net/10451/17736
ISSN: 0031-9384
Versão do Editor: The definitive version is available at http://www.sciencedirect.com/
Aparece nas colecções:FM-IB-Artigos em Revistas Internacionais

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