Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/17741
Título: Effects of choline on hemorheological properties and NO metabolism of human erythrocytes
Autor: Santos, Tiago
Mesquita, Rui
Martins e Silva, João
Saldanha, Carlota
Palavras-chave: Choline
Hemorheology
NO
Nitrites
Data: 2003
Editora: IOS Press
Citação: Clinical Hemorheology and Microcirculation 29 (2003) 41–51
Resumo: Purpose of the study: To determine the effects of choline on red blood cell membrane properties and NO metabolism. Material and methods: Aliquots of venous blood from eleven healthy subjects were incubated in vitro with choline concentrations 10−10 to 10−3 M. The following parameters were determined: erythrocyte deformability, aggregation and membrane lipid fluidity, plasma K+, Na+, Ca2+, total blood haemoglobin and methemoglobin concentrations. Additionally, plasma and intra-erythrocyte nitrites concentrations were measured. Results: Choline increases erythrocyte deformability at lower shear stresses, decreases erythrocyte aggregation, increases membrane lipid fluidity, and decreases of Na+ plasma concentrations. We also find an increase of nitrites concentration both in the plasma and in the intra-erythrocyte compartment. Conclusion: Choline induces changes on erythrocyte membrane properties, Na+ plasma concentration, and NO metabolites concentrations.
Descrição: © 2003 – IOS Press. All rights reserved
Peer review: yes
URI: http://iospress.metapress.com/content/y1p34rf38jjf49kr/?p=c84fcbaf339c48f996b15e7c4a71cffe&pi=6
http://hdl.handle.net/10451/17741
ISSN: 1386-0291
Aparece nas colecções:FM-IB-Artigos em Revistas Internacionais

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