Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/17891
Título: Ethanol and erythrocyte membrane interaction: a hemorheologic perspective
Autor: Mesquita, R.
Gonçalves, M. I.
Dias, S.
Sargento, L.
Saldanha, C.
Martins e Silva, J.
Data: 1999
Editora: IOS Press
Citação: Clinical Hemorheology and Microcirculation 21 (1999) 95–98
Resumo: Previous studies have documented structural and functional changes induced by ethanol–erythrocyte membrane interaction. In order to perform an in vitro study on the effect of different ethanol concentrations on erythrocyte hemorheologic properties, blood samples were collected from 21 male donors at the Hospital of Santa Maria. Whole blood aliquots were incubated with ethanol solutions of rising concentrations. The following parameters were measured: erythrocyte aggregation, haemoglobin, carboxyhaemoglobin and methaemoglobin concentrations, hematocrit, plasma osmolality and erythrocyte membrane fluidity (fluorescence polarisation probes TMA-DPH and DPH). With ethanol blood concentrations of 45 mM a rise in plasma osmolality (0.352 Osm/kg H2O vs 0.310 Osm/kg H2O; p < 0.001) was verified. With 67 mM concentration a decrease of erythrocyte aggregation (11.03 vs 12.81; p < 0.05) and an increase in plasma osmolality (0.380 Osm/kg H2O vs 0.310 Osm/kg H2O;p < 0.001) were obtained. In conclusion, ethanol only changes erythrocyte aggregation for a concentration of 67 mM. These data could lead to future changes in therapeutic approaches to situations such as alcoholic coma.
Descrição: © 1999 – IOS Press. All rights reserved
Peer review: yes
URI: http://iospress.metapress.com/content/455nmpjftq4ybkj7/?p=4d7a0fdd1d23412eabfc243594816b78&pi=2
ISSN: 1386-0291
Versão do Editor: The definitive version is available at http://iospress.metapress.com/content/103148/?sortorder=asc
Aparece nas colecções:FM-IB-Artigos em Revistas Internacionais

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