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|Título:||Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia|
Foxall, R. B.
Marcelino, J. M.
Soares, R. S.
Baptista, A. P.
Victorino, R. M.
Sousa, A. E.
B-cell activating factor
|Editora:||Lippincott Williams & Wilkins|
|Citação:||AIDS 2012, 26:1607–1617|
|Resumo:||Objective: Memory B-cell loss has long been recognized as an important contributor to HIV immunodeficiency. HIV-2 infection, which is characterized by a slow rate of progression to AIDS and reduced to undetectable viremia, provides a unique model to investigate B-cell disturbances. Design and methods: B-cell subsets were evaluated in 38 HIV-2-infected individuals, along with markers of T-cell activation and serum levels of immunoglobulins and a major B-cell homeostatic cytokine, B-cell activating factor (BAFF). Untreated HIV-1-infected and seronegative control individuals were studied in parallel. Statistical analysis was performed using Mann–Whitney tests and Spearman's correlations. Results: We found that HIV-2 was associated with significant depletion of both unswitched (CD27+IgD+) and switched (CD27+IgDneg) memory B-cells that directly correlated with T-cell activation, even in individuals with undetectable plasma viral load. Nevertheless, the presence of detectable viremia, even at low levels, was associated with significant memory B-cell loss and higher BAFF levels. Moreover, these alterations were not recovered by antiretroviral-therapy, as treated HIV-2-infected patients showed more pronounced B-cell disturbances, possibly related to their extended length of infection. Conclusion: These first data regarding B-cell imbalances during HIV-2 infection show that, irrespective of viremia, prolonged HIV infection leads to irreversible damage of memory B-cell homeostasis.|
|Descrição:||© 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins|
|Versão do Editor:||The definitive version is available http://journals.lww.com/pages/default.aspx|
|Aparece nas colecções:||FM - Artigos em Revistas Internacionais|
IMM - Artigos em Revistas Internacionais
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