Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/18298
Título: Repairing thymic function
Autor: Nunes-Cabaço, H.
Sousa, A. E.
Data: Jun-2013
Editora: Lippincott Williams & Wilkins
Citação: Current Opinion in Organ Transplantation, Volume 18 - Issue 3 - p 363–368
Resumo: Purpose of review: Maintenance of T-cell function and modulation of tolerance are critical issues in organ transplantation. The thymus is the primary organ for T-cell generation, and a preserved thymic function is essential for a self-tolerant diverse T-cell repertoire. Transplant procedures and related immunosuppressive drugs may hinder thymic integrity and function. We review here the recent advances in understanding the regulation of the unique thymic microenvironment with relevance for the field of transplantation. Recent findings: Recent studies have assigned a role for IL-22 in the regeneration of thymic epithelium, and for microRNAs in the modulation of its survival and function. The interplay of key molecules in the cross-talk between thymic epithelial cells and thymocytes was depicted, opening new perspectives for the in-vitro recapitulation of T-cell development and for thymic transplantation. Additionally, the thymus was shown to be able to sustain thymocyte progenitor renewal. Summary: These findings open new venues of research toward therapeutic interventions in the endogenous thymus to modulate or reconstitute the immune system; thymic transplantation; and the future development of artificial thymus, which would represent an important tool to achieve tolerance across the histocompatibility barriers.
Descrição: © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
Peer review: yes
URI: http://dx.doi.org/10.1097/MOT.0b013e3283615df9
ISSN: 1087-2418
Versão do Editor: The definitive version is available http://journals.lww.com/pages/default.aspx
Aparece nas colecções:FM - Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

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