Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/18303
Título: Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.
Autor: Cavaleiro, R.
Tendeiro, R.
Foxall, R. B.
Soares, R. S.
Baptista, A. P.
Gomes, P.
Valadas, E.
Victorino, R. M.
Sousa, A. E.
Palavras-chave: HIV-2
AIDS
Monocytes
Myeloid Dendritic Cells
PD-L1
Immune Activation
Data: 2013
Citação: JID 2013:207 (1 June)
Resumo: Monocytes and myeloid dendritic cells (mDCs) are important orchestrators of innate and human immunodeficiency virus (HIV)-specific immune responses and of the generalized inflammation that characterizes AIDS progression. To our knowledge, we are the first to investigate monocyte and mDC imbalances in HIV type 2 (HIV-2)-positive patients, who typically feature reduced viremia and slow disease progression despite the recognized ability of HIV-2 to establish viral reservoirs and overcome host restriction factors in myeloid cells. We found a heightened state of monocyte and mDC activation throughout HIV-2 infection (characterized by CD14(bright)CD16(+) expansion, as well as increased levels of soluble CD14, HLA-DR, and CD86), together with progressive mDC depletion. Importantly, HIV-2-positive patients also featured overexpression of the inhibitory molecule PD-L1 on monocytes and mDCs, which may act by limiting the production of proinflammatory molecules. These data, from patients with a naturally occurring form of attenuated HIV disease, challenge current paradigms regarding the role of monocytes in HIV/AIDS and open new perspectives regarding potential strategies to modulate inflammatory states.
Descrição: © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
Peer review: yes
URI: http://jid.oxfordjournals.org/content/207/11/1730.long
http://dx.doi.org/ 10.1093/infdis/jit085
http://hdl.handle.net/10451/18303
ISBN: 0022-1899
Versão do Editor: The definitive version is available at http://www.oxfordjournals.org/en/
Aparece nas colecções:FM - Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

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