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|Título:||Monocyte and myeloid dendritic cell activation occurs throughout HIV type 2 infection, an attenuated form of HIV disease.|
Foxall, R. B.
Soares, R. S.
Baptista, A. P.
Victorino, R. M.
Sousa, A. E.
Myeloid Dendritic Cells
|Citação:||JID 2013:207 (1 June)|
|Resumo:||Monocytes and myeloid dendritic cells (mDCs) are important orchestrators of innate and human immunodeficiency virus (HIV)-specific immune responses and of the generalized inflammation that characterizes AIDS progression. To our knowledge, we are the first to investigate monocyte and mDC imbalances in HIV type 2 (HIV-2)-positive patients, who typically feature reduced viremia and slow disease progression despite the recognized ability of HIV-2 to establish viral reservoirs and overcome host restriction factors in myeloid cells. We found a heightened state of monocyte and mDC activation throughout HIV-2 infection (characterized by CD14(bright)CD16(+) expansion, as well as increased levels of soluble CD14, HLA-DR, and CD86), together with progressive mDC depletion. Importantly, HIV-2-positive patients also featured overexpression of the inhibitory molecule PD-L1 on monocytes and mDCs, which may act by limiting the production of proinflammatory molecules. These data, from patients with a naturally occurring form of attenuated HIV disease, challenge current paradigms regarding the role of monocytes in HIV/AIDS and open new perspectives regarding potential strategies to modulate inflammatory states.|
|Descrição:||© The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.|
|Versão do Editor:||The definitive version is available at http://www.oxfordjournals.org/en/|
|Aparece nas colecções:||FM - Artigos em Revistas Internacionais|
IMM - Artigos em Revistas Internacionais
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