Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/18304
Título: Monocyte-mediated T cell suppression by HIV-2 envelope proteins
Autor: Cavaleiro, R.
Brunn, G. J.
Albuquerque, A. S.
Victorino, R. M.
Platt, J. L.
Sousa, A. E.
Palavras-chave: HIV
Host/pathogen interactions
Immunopathology
Monocytes
Toll-like receptors
Data: 2007
Editora: Wiley
Citação: Eur. J. Immunol. 2007. 37: 3435–3444
Resumo: HIV-2 is associated with an attenuated form of HIV disease. We investigate here the immunosuppressive effects of the HIV-2 envelope protein, gp105. We found that gp105 suppresses activation of T cells through a monocyte-mediated mechanism. Suppression of T cell activation by gp105 depends on contact between monocytes and T cells, but not on CD4+CD25+ T cells. The TLR4 pathway is likely involved, since gp105 activates TLR4 signaling and induces TNF-α production by monocytes. Immunosuppression is viewed as the main pathophysiologic consequence of infection by HIV. However, the main immunologic defect caused by HIV, depletion of T cells, requires T cell activation. Our findings are consistent with a new concept that HIV-2 envelope proteins act on monocytes to suppress T cell activation and that this property may contribute to the benign course of HIV-2. We hypothesize that the HIV-2 envelope immunosuppressive properties limit bursts of T cell activation, thus reducing viremia and contributing to the slow rate of disease progression that characterizes HIV-2 disease.
Descrição: © 2007 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Peer review: yes
URI: http://onlinelibrary.wiley.com/doi/10.1002/eji.200737511/full
http://dx.doi.org/ 10.1002/eji.200737511
http://hdl.handle.net/10451/18304
ISSN: 0014-2980
Versão do Editor: The definitive version is available at http://onlinelibrary.wiley.com
Aparece nas colecções:FM - Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

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