Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/18440
Título: Preserved monocyte-derived dendritic cell differentiation and maturation in the presence of HIV-2 envelope
Autor: Cavaleiro, R.
Baptista, A. P.
Foxall, R. B.
Victorino, R. M.
Sousa, A. E.
Palavras-chave: HIV-2
HIV envelope proteins
HIV immunopathogenesis
Dendritic cells
Data: 2009
Editora: Mary Ann Liebert
Citação: AIDS Research and Human Retroviruses. April 2009, 25(4): 425-431
Resumo: Dendritic cells (DCs) are fundamental for the initiation of immune responses and are important players in AIDS immunopathogenesis. Impairment of DC function may result from bystander effects of HIV-1 envelope proteins independently of direct HIV-1 infection. HIV-2 envelope proteins are thought to interact with a broader range of receptors than those of HIV-1, and have been shown to have T cell immunosuppressive properties mediated by monocytes. The effects of HIV-2 envelope on DC differentiation and maturation were investigated. The modulatory properties of the HIV-2 envelope on DC generated from monocytes were assessed using both recombinant proteins (HIV-2(ROD) and HIV-2(ALI)) and whole chemically inactivated virus (aldrithiol-2-treated HIV-2(ROD)). DC phenotype was assessed by flow cytometry and DC function by their ability to stimulate allogeneic T cells and to produce cytokines. We demonstrate that HIV-2 Env had no effects upon DC differentiation and maturation despite its broad receptor usage and ability to modulate monocyte function. It is plausible to speculate that a reduced ability of the HIV-2 Env to impair myeloid DC function could represent a contributory factor to the relatively benign course of HIV-2 disease.
Descrição: © 2012 Mary Ann Liebert, Inc. publishers. All rights reserved, USA and worldwide.
Peer review: yes
URI: http://dx.doi.org/ 10.1089/aid.2008.0247
ISSN: 0889-2229
Versão do Editor: The definitive version is available at http://www.liebertpub.com/
Aparece nas colecções:IMM - Artigos em Revistas Internacionais
FM-LIC - Artigos em Revistas Internacionais

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