Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/18442
Título: Comparison of the frequency of interleukin (IL)-2-, interferon-γ-, and IL-4-producing T cells in 2 diseases, human immunodeficiency virus types 1 and 2, with distinct clinical outcomes
Autor: Sousa, Ana E.
Chaves, Ana F.
Loureiro, Ana
Victorino, Rui M. M.
Data: 2001
Editora: Oxford University Press
Citação: The Journal of Infectious Diseases 2001;184:552–9
Resumo: Human immunodeficiency virus (HIV) type 2 infection is associated with a better clinical outcome, slower rates of CD4 T cell decline, and lower viremia than is HIV-1. This study compares HIV-1 and HIV-2 in regard to the percentages of interleukin (IL)–2–, interferon (IFN)–γ–, and IL-4–producing cells at the single-cell level, as determined by flow cytometry. At a given degree of CD4 T cell depletion, the frequency of T cells able to produce IL-2 is better preserved in HIV-2 than in HIV-1 infection, particularly within the CD4 T cell subset. As described for HIV-1 immunodeficiency, HIV-2–positive patients exhibit a marked expansion of terminally differentiated effector CD8 T cells (CD28−CD27−IFN-γ+). However, the proportion of CD8 T cells able to simultaneously produce IL-2 and IFN-γ is higher in HIV-2 disease. Considering the central role of IL-2 as a lymphocyte proliferative and survival factor, these findings provide a possible immunologic basis for the distinct course of HIV-2 immunodeficiency
Descrição: © 2001 by the Infectious Diseases Society of America
Peer review: yes
URI: http://dx.doi.org/10.1086/322804
ISSN: 0022-1899
Versão do Editor: The definitive version is available at http://www.oxfordjournals.org/
Aparece nas colecções:IMM - Artigos em Revistas Internacionais
FM-LIC - Artigos em Revistas Internacionais

Ficheiros deste registo:
Ficheiro Descrição TamanhoFormato 
Comparison_frequency.pdf195,79 kBAdobe PDFVer/Abrir    Acesso Restrito. Solicitar cópia ao autor!

FacebookTwitterDeliciousLinkedInDiggGoogle BookmarksMySpace
Formato BibTex MendeleyEndnote Degois 

Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.