Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/20110
Título: Efficient thymopoiesis contributes to the maintenance of peripheral CD4 T cells during chronic human immunodeficiency virus type 2 infection
Autor: Gautier, D.
Beq, S.
Cortesão, C. S.
Sousa, A. E.
Cheynier, R.
Data: 2007
Editora: American Society for Microbiology
Citação: Journal of Virology, Nov. 2007, p. 12685–12688
Resumo: Human immunodeficiency virus type 2 (HIV-2) infection leads to a lifelong asymptomatic period in the majority of patients. Even in patients with progressive disease, a slow CD4 count decline characterizes the chronic phase of HIV-2 infection, suggesting that peripheral T-cell homeostasis is controlled better following HIV-2 infection than following HIV-1 infection. Herein we showed that, in contrast to HIV-1-infected patients, HIV-2-infected patients demonstrate enhanced thymic function compared to age-matched healthy individuals. The correlation between higher thymic production and lower CD4 T-cell loss in these patients suggests that efficient thymopoiesis is implicated in the long-lasting maintenance of CD4 T-cell counts in HIV-2 disease.
Descrição: © 2007, American Society for Microbiology. All Rights Reserved.
Peer review: yes
URI: http://dx.doi.org/10.1128/JVI.01131-07
ISSN: 0022-538X
Aparece nas colecções:FM-LIC - Artigos em Revistas Internacionais
IMM - Artigos em Revistas Internacionais

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