Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/20122
Título: Regulatory T-Cell development in the human thymus
Autor: Caramalho, Íris
Nunes-Cabaço, Helena
Foxall, Russell B.
Sousa, Ana E.
Palavras-chave: Human thymus
Regulatory T-cells
FOXP3
Regulatory T-cell development
Human thymic defects
Primary immunodeficiency
Data: 2015
Editora: Frontiers
Citação: Frontiers in Immunology | August 2015 | Volume 6 | Article 395
Resumo: The thymus generates a lineage-committed subset of regulatory T-cells (Tregs), best identified by the expression of the transcription factor FOXP3. The development of thymus-derived Tregs is known to require high-avidity interaction with MHC-self peptides leading to the generation of self-reactive Tregs fundamental for the maintenance of self-tolerance. Notwithstanding their crucial role in the control of immune responses, human thymic Treg differentiation remains poorly understood. In this mini-review, we will focus on the developmental stages at which Treg lineage commitment occurs, and their spatial localization in the human thymus, reviewing the molecular requirements, including T-cell receptor and cytokine signaling, as well as the cellular interactions involved. An overview of the impact of described thymic defects on the Treg compartment will be provided, illustrating the importance of these in vivo models to investigate human Treg development.
Descrição: © 2015 Caramalho, Nunes-Cabaço, Foxall and Sousa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Peer review: yes
URI: http://dx.doi.org/10.3389/fimmu.2015.00395
http://hdl.handle.net/10451/20122
ISSN: 1664-3224
Aparece nas colecções:IMM - Artigos em Revistas Internacionais
FM-LIC - Artigos em Revistas Internacionais

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