Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/20162
Título: Effects of acetylcholine and SpermineNONOate on erythrocyte hemorheologic and oxygen carrying properties
Autor: Mesquita, Rui
Pires, Ivo
Saldanha, Carlota
Martins-Silva, João
Data: 2001
Editora: IOS Press
Citação: Clinical Hemorheology and Microcirculation 25 (2001) 153–163
Resumo: Purpose of the study: To determine the effects of acetylcholine and SpermineNONOate – a NO donor – on RBC membrane and oxygen carrying properties. Material and methods: Aliquots of venous blood from eleven heathy subjects were incubated with ACh 10−3 M, ACh 10−5 M, SpermineNONOate 10−5 M and SpermineNONOate 10−4 M. The following parameters were determined: erythrocyte aggregation and deformability, hematocrit, plasma pH, osmolality, K+, Na+, Ca2+ concentrations, hemoglobin, oxyhemoglobin, carboxihemoglobin and methemoglobin concentrations, oxygen saturation of hemoglobin, oxygen and carbon dioxide parcial pressures and p50. Results: In presence of ACh there is an increase of erythrocyte deformability, decrease of erythrocyte aggregation, plasma pH, K+ and Na+ concentration, increase of Ca2+ concentration and p50. In presence of SpermineNONOate there an increase of erythrocyte deformability, plasma pH, decrease of Na+ and Ca2+ concentration, increase of metHb concentration and decrease of p50. Conclusion: Acetylcholine and SpermineNONOate are able to induce changes on RBC membrane and oxygen carrying properties.
Descrição: © 2001 – IOS Press. All rights reserved
Peer review: yes
URI: http://content.iospress.com/journals/clinical-hemorheology-and-microcirculation/25/3,4
http://hdl.handle.net/10451/20162
ISSN: 1386-0291
Versão do Editor: http://content.iospress.com/
Aparece nas colecções:FM-IB-Artigos em Revistas Internacionais

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