Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/20173
Título: The relation between the erythrocyte nitric oxide and hemorheological parameters
Autor: Carvalho, F. A.
Maria, A. V.
Nogueira, J. M. Braz
Guerra, J.
Martins-Silva, J.
Palavras-chave: Nitric oxide
Hemorheology
Acetylcholine
Hypertension
Hypercholesterolemia
Renal transplantation
Data: 2006
Editora: IOS Press
Citação: Clinical Hemorheology and Microcirculation 35 (2006) 341–347
Resumo: We stimulated human erythrocytes obtained from patients with hypercholesterolemia (HC; n = 42), renal transplantation (RT; n = 18) and hypertension (HT; n = 10) with acetylcholine (ACh 10 μM) and measured the amperometric NO production, comparing with the NO levels achieved on erythrocytes of healthy persons (n = 27). We also measured the hemoglobin, hematocrit, erythrocyte aggregation, erythrocyte deformability, plasma viscosity and fibrinogen concentration from human blood samples. The erythrocytes NO levels were of 2.5 ± 0.7 nM (P = 0.038, HC), 2.4 ± 1.1 nM (RT) and 2.2 ± 0.8 nM (HT) against the 2.0 ± 0.8 nM for the control groups. For each group and at each shear stress value, the erythrocytes deformability decreases with the increase of the NO concentration after ACh stimulation. We observed a significant increase of the control values on the erythrocyte aggregation results on each patient group. Besides the lower erythrocyte deformability obtained on HC, RT and HT blood samples, the erythrocytes produced higher NO levels after ACh stimulation than the healthy ones. The power of erythrocyte hemorheological behaviour could be compensated by the NO production at the presence of acetylcholine. We can hypothesises that cholinergic drugs could be used as co-adjuvants of specific therapeutics compounds on these studied diseases.
Descrição: © 2006 – IOS Press and the authors. All rights reserved
Peer review: yes
URI: http://content.iospress.com/articles/clinical-hemorheology-and-microcirculation/ch950
http://hdl.handle.net/10451/20173
ISSN: 1386-0291
Aparece nas colecções:FM-IB-Artigos em Revistas Internacionais

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