Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/20188
Título: Impairment of the erythrocyte membrane fluidity in survivors of acute myocardial infarction. A prospective study
Palavras-chave: Erythrocyte membrane fluidity
Acute myocardial infarction
Prospective study
Data: 1999
Editora: IOS Press
Citação: Clinical Hemorheology and Microcirculation 20 (1999) 111–116
Resumo: Erythrocytes have to constantly adapt themselves to the varying circulatory system shear stress forces and capillaries diameter. Membrane lipid and protein content have an important role in determining the erythrocyte shape and are main determinants of the membrane solid and fluid behavior which enables the erythrocyte to respond to the outer environment modifications. Membrane fluidity is an inverse index of membrane microviscosity. The aim of the present work is to evaluate prospectively in three periods of time (discharge, after 6 months and one year later) in survivors of an acute myocardial infarction (AMI) the erythrocyte membrane fluidity (outer and inner bilayer) and establish a relation with the cardiovascular events or need of coronary revascularization during a two year clinical follow up. Sixty survivors of acute myocardial infarction were recruited during 1994–96 and were prospectively studied in three periods (discharge, 6 months and after one year), and were compared with a control group (n = 36). Membrane lipid fluidity was determined by means of fluorescence polarization with two probes: 1,6-diphenyl-1,2,5-hexatriene (DPH) and 1,4-trimethylamine 6-phenyl hexa-1,3,5-triene (TMA-DPH), for the characterisation of the hydrophobic and external polar region, respectively. The hydrophobic region was more rigidified (p < 0:01) in the erythrocytes from AMI patients, in relation to the control group. During the time of the study there was a progressive erythrocyte membrane rigidification (DPH p < 0:001; TMA-DPH p < 0:001). We found no relation between erythrocyte membrane fluidity and the coronary risk factors, cardiovascular events or the need of coronary revascularization during the clinical follow-up. In conclusion, after the myocardial infarction erythrocyte membrane of AMI survivors becomes more rigid with time, which could contribute to the decreased erythrocyte deformability and the increased blood viscosity previously described in this group of patients.
Descrição: © 1999 – IOS Press. All rights reserved
Peer review: yes
URI: http://content.iospress.com/journals/clinical-hemorheology-and-microcirculation/20/2
ISSN: 1386-0291
Versão do Editor: http://content.iospress.com/journals/clinical-hemorheology-and-microcirculation
Aparece nas colecções:FM-IB-Artigos em Revistas Internacionais

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