Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/20918
Título: In vitro release studies of methylmethacrylate liberation from acrylic cement powder
Autor: Bettencourt, A
Calado, A
Amaral, J
Vale, FM
Rico, JMT
Monteiro, J
Lopes, A
Pereira, L
Castro, M
Palavras-chave: Pharmacology & Pharmacy
Data: 2000
Editora: ELSEVIER SCIENCE BV
Citação: International Journal of Pharmaceutics. 2000;197(1-2):161-168
Resumo: Bone cement or polymethylmethacrylate (PMMA) is commonly used for anchoring cemented prosthesis to the bone. Cytotoxic effect of culture media exposed to PMMA powder may be related with long term problems associated with acrylic cement application, being the monomer (methylmethacrylate) one of the cement's component partly responsible for the cytotoxic effect. The present work reports the studies of monomer release from acrylic bone cement powder under different experimental conditions: setting time of PMMA (in solution and air) and different culture media composition. High-performance liquid chromatography was used for the determination of residual monomer. Mathematical models were applied to experimental dissolution data revealing that monomer release is lightly affected by the studied variables. The monomer release seems to be a surface phenomena, suggesting that the possible actions of monomer will mainly be due to the initial loss of non polymerized monomer rather than to further depolymerization of the already polymerized cement. (C) 2000 Elsevier Science B.V. All rights reserved.
Peer review: yes
URI: http://hdl.handle.net/10451/20918
DOI: https://doi.org/10.1016/S0378-5173(99)00468-8
ISSN: 0378-5173
Versão do Editor: http://www.sciencedirect.com/science/article/pii/S0378517399004688
Aparece nas colecções:FF - Produção Científica 2000-2009

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