Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/20924
Título: Rearranged jatrophane-type diterpenes from Euphorbia species. Evaluation of their effects on the reversal of multidrug resistance
Autor: Madureira, AM
Ferreira, MJU
Gyemant, N
Ugocsai, K
Ascenso, JR
Abreu, PM
Hohmann, J
Molnar, J
Palavras-chave: Plant Sciences
Chemistry, Medicinal
Pharmacology & Pharmacy
Data: 2004
Editora: GEORG THIEME VERLAG KG
Citação: PLANTA MEDICA. - Vol. 70, n. 1 (JAN 2004), p. 45-49
Resumo: The rearranged jatrophane-type diterpenes (1 - 3), isolated from the Me2CO extracts of Euphorbia portlandica and Euphorbia segetalis, were examined for their effects on multidrug resistance (MDR) in mouse lymphoma cells. Compounds 2 and 3 revealed to be active with the latter being more active than the positive control verapamil, a known resistance modifier. The new compound 1, named portlandicine, was isolated from Euphorbia portlandica and its structure characterised by high-field NMR spectroscopic methods including 2D NMR techniques: COSY, HMQC, HMBC and NOESY. The known diterpene 2, together with aleuritolic acid (4), oleanolic acid (5), and betulin diacetate (6), were also isolated from the same species.
URI: http://hdl.handle.net/10451/20924
DOI: http://dx.doi.org/10.1055/s-2004-815454
ISSN: 0032-0943
Aparece nas colecções:FF - Produção Científica 2000-2009

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