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|Título:||Effect of cycloartanes on reversal of multidrug resistance and apoptosis induction on mouse lymphoma cells|
|Editora:||INT INST ANTICANCER RESEARCH|
|Citação:||ANTICANCER RESEARCH. - Vol. 24, n. 2B (MAR-APR 2004), p. 859-864|
|Resumo:||The ability of fifteen cycloartanes, isolated from Euphorbia species, to reverse multidrug resistance (MDR) and apoptosis induction in L5178Y mouse lymphoma cells, including its multidrug-resistant subline, was studied by flow cytometry. Reversion of MDR was investigated using a standard functional assay with rhodamine 123 as a fluorescent substrate analogue. For the evaluation of apoptosis, the cells were stained with FITC-labeled annexin V and propidium iodide. The majority of the compounds were able to reverse MDR of the tested human MDR1 gene-transfected mouse lymphoma cells. Some of the compounds were able to induce moderate apoptosis in the PAR cell line, but this effect was less effective on multidrug-resistant cells. The results indicate that cycloartanes can be substrates of ABC transporters, which might compete with certain anticancer chemotherapeutics.|
|Aparece nas colecções:||FF - Produção Científica 2000-2009|
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