Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/20950
Título: Evidence for zinc protection against 2,5-hexanedione toxicity by co-exposure of rats to zinc chloride
Autor: Mateus, ML
dos Santos, APM
Batoreu, MC
Palavras-chave: Toxicology
Data: 2000
Editora: JOHN WILEY & SONS LTD
Citação: JOURNAL OF APPLIED TOXICOLOGY. - Vol. 20, n. 3 (MAY-JUN 2000), p. 211-214
Resumo: The protective role of zinc against the toxic effects of 2,5-hexanedione (2,5-HD), the main neurotoxic metabolite of n-hexane, was investigated by studying the interference of zinc on the toxicokinetics of 2,5-HD, Six groups of Wistar rats were exposed for 3 days to diets containing 2,5-HD, zinc chloride and 2,5-HD+zinc chloride. The amounts of pyrroles and free and total 2,5-HD in urine were determined using Ehrlichs's reagent and gas chromatography/flame ionization detection, respectively. The results show that after the first day of co-exposure (ZnCl2+2,5-HD) there was a significant decrease in the excretion of pyrroles and free 2,5-HD in rats exposed to the chemical mixture when compared to the pyrroles and free 2,5-HD excreted in rats exposed to 2,5-HD alone. However, no significant decrease was observed in the urinary excretion of total 2,5-HD (free 2,5-HD + preformed 2,5-HD). Suggestions are made about the role played by this metal ion in inhibiting pyrrole formation. Copyright (C) 2000 John Wiley & Sons, Ltd.
URI: http://hdl.handle.net/10451/20950
ISSN: 0260-437X
Aparece nas colecções:FF - Produção Científica 2000-2009

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