Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/20976
Título: New approach on the development of a mucosal vaccine against strangles
Systemic and mucosal immune responses in a mouse model
Autor: Florindo, H. F.
Pandit, S.
Goncalves, L. M. D.
Alpar, H. O.
Almeida, A. J.
Palavras-chave: Immunology
Medicine, Research & Experimental
Data: 2009
Citação: VACCINE. - Vol. 27, n. 8 (FEB 18 2009), p. 1230-1241
Resumo: Streptococcus equi subspecies equi affects animals of Equidae family and is the causative agent of strangles, an acute, extremely contagious and deadly disease. Prolonged periods of protection associated to absence of serious adverse reactions were not yet achieved. Thus, this experimental work is focused oil the Study of mucosal, humoral and cellular immune responses developed in a mouse model, after the intranasal administration of S. equi antigens associated by adsorption or encapsulation to poly(lactic acid) nanospheres, modified by mucoadhesive polymers and absorption enhancers. Particles fitted the nanometer range and proteins integrity and antigenicity were not affected. PLA nanospheres induced a mixed Th1 and Th2 response, being therefore potential Carriers for the delivery of S. equi antigens. (C) 2008 Elsevier Ltd. All rights reserved.. - Fundacao para a Ciencia e Tecnologia ; Ministerio da Ciencia e da Tecnologia, Portugal [SFRH/BD/14300/2003, POCI/BIO/59147/2004, PPCDT/BIO/59147/2004]. - Authors are grateful to Dr. David McCarthy (The London School of Pharmacy, UK) for the SEM analysis. This work was Supported by Fundacao para a Ciencia e Tecnologia, Ministerio da Ciencia e da Tecnologia, Portugal (SFRH/BD/14300/2003, POCI/BIO/59147/2004 and PPCDT/BIO/59147/2004).
URI: http://hdl.handle.net/10451/20976
DOI: http://dx.doi.org/10.1016/j.vaccine.2008.12.004
ISSN: 0264-410X
Aparece nas colecções:FF - Produção Científica 2000-2009

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