Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21005
Título: Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat
Autor: Sepodes, Bruno
Maio, Rui
Pinto, Rui
Sharples, Edward
Oliveira, Pedro
McDonald, Michelle
Yaqoob, Muhammad
Thiemermann, Christoph
Mota-Filipe, Helder
Palavras-chave: Surgery
Transplantation
Data: 2006
Editora: BLACKWELL PUBLISHING
Citação: TRANSPLANT INTERNATIONAL. - Vol. 19, n. 11 (NOV 2006), p. 919-926
Resumo: Recently, erythropoietin was shown to have both hematopoietic as well as tissue-protective properties. Erythropoietin (EPO) had a protective effect in animal models of cerebral ischemia, mechanical trauma of the nervous system, myocardial infarction, and ischemia-reperfusion (I/R) injury of the kidney. It is not known whether EPO protects the liver against I/R injury. Using a rat model of liver I/R injury, we aimed to determine the effect of the administration of human recombinant erythropoietin (rhEPO) on liver injury. Rats were subjected to 30 min of liver ischemia followed by 2 h of reperfusion. When compared with the sham-operated rats, I/R resulted in significant rises in the serum levels of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, gamma-glutamyl transferase, tissue lipid peroxidation, caspase-3 activity and altered histology. Administration of rhEPO 5 min before ischemia was able to reduce the biochemical evidence of liver injury; however, this protection was not evident when rhEPO was administered 5 min before reperfusion. Mechanistically, early administration of rhEPO was able to reduce the oxidative stress and caspase-3 activation, suggesting the subsequent reduction of apoptosis. This study provides the first evidence that rhEPO causes a substantial reduction of the liver injury induced by I/R in the rat.
URI: http://hdl.handle.net/10451/21005
DOI: http://dx.doi.org/10.1111/j.1432-2277.2006.00366.x
ISSN: 0934-0874
Aparece nas colecções:FF - Produção Científica 2000-2009

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