Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21008
Título: Exercise training is associated with improved levels of C-reactive protein and adiponectin in ZDF (type 2) diabetic rats
Autor: de Lemos, Edite Teixeira
Reis, Flavio
Baptista, Sofia
Pinto, Rui
Sepodes, Bruno
Vala, Helena
Rocha-Pereira, Petronila
Silva, Alice Santos
Teixeira, Frederico
Palavras-chave: Medicine, Research & Experimental
Data: 2007
Editora: INT SCIENTIFIC LITERATURE, INC
Citação: MEDICAL SCIENCE MONITOR. - Vol. 13, n. 8 (AUG 2007), p. BR172-BR174
Resumo: Background: Chronic tow-grade systemic inflammation is a feature of such chronic diseases as cardiovascular disease and type 2 diabetes (T2D). There is evidence that regular exercise is effective as a treatment in these situations. This study intended to assess the levels of two inflammatory mediators, C-creative protein (CRP) and adiponectin, in Zucker Diabetic Fatty (ZDF, fa/fa) rats, an experimental model of T2D, and to determine whether exercise-induced changes in insulin resistance could be explained by modifications in these inflammation markers. Material/Methods: Male ZDF (Gmi fa/fa) rats and their littermates (Gmi +/+), aged 8 weeks, were randomly assigned in two groups: an exercise trained and a sedentary one. Swimming was conducted 1 h/day 3 days/week for 12 weeks. The rats were sacrificed 48 h after the last rotund of exercise. Rats had their body weight, insulin, adiponectin, CRP, as well as glucose, total cholesterol, triglycerides, MDA, and SOD measured and HOMA-IR calculated before and after the 12-week swimming training. Results: In the ZDF (fa/fa) rats underwent swimming exercise, all the metabolic abnormalities were totally or partially prevented (p 0.001), namely the hyperglycemic, hyperinsulinemic, and dyslipidemic pattern observed in their sedentary counterparts. Furthermore, even without body weight change, a plasma adiponectin increase (28.0%) and a CRP decrease (12.7%) were also observed. Conclusion: A 12-week thrice-weekly swimming training was associated with improved measures of chronic inflammation markers as measured by adiponectin and CRP. Moreover, improvements in insulin sensitivity resulting from swimming exercise appeared to be related to changes in these inflammatory mediators.
URI: http://hdl.handle.net/10451/21008
ISSN: 1234-1010
Aparece nas colecções:FF - Produção Científica 2000-2009

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