Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21098
Título: Bile acids and apoptosis modulation
an emerging role in experimental Alzheimer's disease
Autor: Ramalho, Rita M.
Viana, Ricardo J. S.
Low, Walter C.
Steer, Clifford J.
Rodrigues, Cecilia M. P.
Palavras-chave: Biochemistry & Molecular Biology
Cell Biology
Medicine, Research & Experimental
Data: 2008
Citação: TRENDS IN MOLECULAR MEDICINE. - Vol. 14, n. 2 (FEB 2008), p. 54-62
Resumo: The potential role of apoptosis in Alzheimer's disease (AD) has been an area of intense research in recent years. Ursodeoxycholic acid (UDCA) and its taurine-conjugate, tauroursodeoxycholic acid (TUDCA) are endogenous bile acids that act as potent inhibitors of apoptosis. Their therapeutic effects have been tested in many experimental pathological conditions, including neurological disorders, such as AD. TUDCA regulates precise transcriptional and post-transcriptional events that impact mitochondrial function in neurons. TUDCA not only stabilizes the mitochondrial membrane and prevents Bax translocation, inhibiting the release of cytochrome c and the activation of caspases, but also interferes with upstream factors, including cell cycle-related proteins. In addition, TUDCA is capable of inducing survival pathways. Here, we review the role of apoptosis in AD and discuss the therapeutic potential of TUDCA in treating this disease.
URI: http://hdl.handle.net/10451/21098
DOI: http://dx.doi.org/10.1016/j.molmed.2007.12.001
ISSN: 1471-4914
Aparece nas colecções:FF - Produção Científica 2000-2009

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