Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21131
Título: Effect of abietane diterpenes from Plectranthus grandidentatus on T- and B-lymphocyte proliferation
Autor: Cerqueira, F
Cordeiro-Da-Silva, A
Gaspar-Marques, C
Simoes, F
Pinto, MMM
Nascimento, MSJ
Palavras-chave: Biochemistry & Molecular Biology
Chemistry, Medicinal
Chemistry, Organic
Data: 2004
Editora: PERGAMON-ELSEVIER SCIENCE LTD
Citação: BIOORGANIC & MEDICINAL CHEMISTRY. - Vol. 12, n. 1 (2004), p. 217-223
Resumo: Five known abietane diterpenes of the royleanone and coleon type, namely, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4) and coleon U (5), isolated from Plectranthus grandidentatus, were evaluated for their effect on the proliferation of human lymphocytes induced by the mitogen PHA. All except 4, showed a dose-dependent suppressor effect, with 3 yielding the most potent antiproliferative activity, followed by 5. These two compounds, that represent diterpenes of the royleanone and coleon type respectively, were also shown to be potent inhibitors of mouse splenocyte proliferation induced by ConA or LPS mitogens. However, the sensitivity of ConA-stimulated splenocytes to their suppressive effect was higher, suggesting a preferential inhibition of T-lymphocyte proliferation. The antiproliferative activity of 3 seemed to be exerted without affecting the expression of the lymphocyte activation marker CD69. On the contrary, 5 was shown to reduce the expression of CD69 of TCD8(+) and B-cells, suggesting a relationship between its antiproliferative effect and the expression of this early marker of activation on these cell populations. The capacity of 5 to induce apoptosis on ConA-stimulated splenocytes could also be related with its antiproliferative activity. (C) 2003 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10451/21131
DOI: http://dx.doi.org/10.1016/j.bmc.2003.10.006
ISSN: 0968-0896
Aparece nas colecções:FF - Produção Científica 2000-2009

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