Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21153
Título: GSTpi Expression in MPTP-Induced Dopaminergic Neurodegeneration of C57BL/6 Mouse Midbrain and Striatum
Autor: Castro-Caldas, Margarida
Carvalho, Andreia Neves
Peixeiro, Isabel
Rodrigues, Elsa
Lechner, Maria Celeste
Gama, Maria Joao
Palavras-chave: Biochemistry & Molecular Biology
Data: 2009
Citação: JOURNAL OF MOLECULAR NEUROSCIENCE. - Vol. 38, n. 2 (JUN 2009), p. 114-127
Resumo: MPTP-induced dopaminergic neurotoxicity involves major biochemical processes such as oxidative stress and impaired energy metabolism, leading to a significant reduction in the number of nigrostriatal dopaminergic neurons. Glutathione S-transferase pi (GSTpi) is a phase II detoxifying enzyme that provides protection of cells from injury by toxic chemicals and products of oxidative stress. In humans, polymorphisms of GSTP1 affect substrate selectivity and stability increasing the susceptibility to parkinsonism-inducing effects of environmental toxins. Given the ability of MPTP to increase the levels of reactive oxygen species and the link between altered redox potential and the expression and activity of GSTpi, we investigated the effect of MPTP on GSTpi cellular concentration in an in vivo model of Parkinson's disease. The present study demonstrates that GSTpi is actively expressed in both substantia nigra pars compacta and striatum of C57BL/6 mice brain, mostly in oligodendrocytes and astrocytes. After systemic administration of MPTP, GSTpi expression is significantly increased in glial cells in the vicinity of dopaminergic neurons cell bodies and fibers. The results suggest that GSTpi expression may be part of the mechanism underlying the ability of glial cells to elicit protection against the mechanisms involved in MPTP-induced neuronal death.. - Fundacao para a Ciencia e a Tecnologia and FEDER (POCI 2010) [POCI/SAU-FCF/58171/2004]. - Supported by Fundacao para a Ciencia e a Tecnologia and FEDER (POCI 2010): project POCI/SAU-FCF/58171/2004
URI: http://hdl.handle.net/10451/21153
DOI: http://dx.doi.org/10.1007/s12031-008-9141-z
ISSN: 0895-8696
Aparece nas colecções:FF - Produção Científica 2000-2009

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