Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21220
Título: Nitric oxide synthase/guanylate cyclase pathway modulates the rat vas deferens contractility induced by phenylephrine
Autor: Pinto, R
Mota-Filipe, H
Lima, BS
Palavras-chave: Pharmacology & Pharmacy
Toxicology
Data: 2002
Editora: BLACKWELL MUNKSGAARD
Citação: PHARMACOLOGY & TOXICOLOGY. - Vol. 91, n. 4 (OCT 2002), p. 179-184
Resumo: The involvement of the nitric oxide synthase/soluble guanylate cyclase pathway on the modulation of phenylephrine-induced contractility in the rat vas deferens was investigated. Phenlylephrine-concentration response curves were obtained in absence and in presence of inhibitors, N-G-Nitro-L-arginine (L-NOARG), N-G-Nitro-L-arginine methyl esther (L-NAME) or N-G-monomethyl-L-arginine (L-NMMA) or GC inhibitior, 1H-(1,2,4)-oxadiaziol-(4,3-a)quinoxalin-1-one (ODQ) or nitric oxide donor, 3-morpholinosydnonimine hydrochloride (SIN-1) alone or together with L-NMMA or ODQ. Both nitric oxide synthase and GC inhibitors reduced the Phe-E-max SIN-1 alone did not change phenylephrine-induced responses and it could reverse the L-NMMA effect but not ODQ effect. The reduction of the phenylephrine-induced contractility obtained in consequence of the inhibition of the nitric oxide/GC pathway suggest that, in the rat vas deferens, despite its well identified relaxant properties, nitric oxide potentiates the contractility induced by adrenergic stimulation.
URI: http://hdl.handle.net/10451/21220
ISSN: 0901-9928
Aparece nas colecções:FF - Produção Científica 2000-2009

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