Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21235
Título: Optimisation of supercritical carbon dioxide systems for complexation of naproxen
Beta-cyclodextrin
Autor: Junco, S
Casimiro, T
Ribeiro, N
Da Ponte, MN
Marques, HMC
Palavras-chave: Chemistry, Multidisciplinary
Crystallography
Data: 2002
Editora: KLUWER ACADEMIC PUBL
Citação: JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY. - Vol. 44, n. 40269 (DEC 2002), p. 69-73
Resumo: Supercritical carbon dioxide (scCO(2)) offers several attractive scenarios for the pharmaceutical processing as an alternative to aqueous and organic solvents. In this work naproxen, a widely used non steroidal anti-inflammatory drug with analgesic and anti-inflammatory properties, was chosen as a model drug. Its complexation with cyclodextrins improves the rate and extent of dissolution of the drug, increase its rate of absorption and may reduce the unpleasant side-effects of the drug. The interest in using this supercritical technology led us to develop an experimental unit for the use of supercritical CO2 as a processing medium for the complexation of naproxen with beta cyclodextrin (CD).
URI: http://hdl.handle.net/10451/21235
ISSN: 0923-0750
Aparece nas colecções:FF - Produção Científica 2000-2009

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