Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21237
Título: A comparative study of naproxen - Beta cyclodextrin complexes prepared by conventional methods and using Supercritical carbon dioxide
Autor: Junco, S
Casimiro, T
Ribeiro, N
Da Ponte, MN
Marques, HC
Palavras-chave: Chemistry, Multidisciplinary
Crystallography
Data: 2002
Editora: KLUWER ACADEMIC PUBL
Citação: JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY. - Vol. 44, n. 40269 (DEC 2002), p. 117-121
Resumo: Naproxen is a poorly soluble anti-inflammatory drug, the solubility of which can be enhanced by complexation with betacyclodextrin. Besides that, the inclusion complex reduces the incidence of gastrointestinal side effects of the drug. The aim of this work was to compare the physicochemical characteristics of the solid complexes prepared by traditional methods (kneading, freeze-drying and spray-drying) and using a supercritical fluid technology. The unusual solvent properties of carbon dioxide above their critical temperature and pressure were exploited in order to prepare inclusion compounds. Complexes prepared using supercritical fluid technology showed similar properties to those of freeze-drying and spray-drying complexes as proved by DSC, FT-IR and UV.
URI: http://hdl.handle.net/10451/21237
ISSN: 0923-0750
Aparece nas colecções:FF - Produção Científica 2000-2009

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