Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21252
Título: Sizing of powders in inhalers with an Aerosizer((R)) according to a mixed experimental factorial design
Autor: Mendes, PJ
Raposo, A
Sousa, JMM
Pinto, JF
Palavras-chave: Engineering, Chemical
Environmental Sciences
Meteorology & Atmospheric Sciences
Data: 2004
Editora: PERGAMON-ELSEVIER SCIENCE LTD
Citação: JOURNAL OF AEROSOL SCIENCE. - Vol. 35, n. 4 (APR 2004), p. 509-527
Resumo: In the present work, the Aerosizer((R)) with the Aerodisperser((R)) is used to assess the size and size distribution of two common dry powder inhalers: Ventilan Rotacaps(TM) (salbutamol sulfate) and Bricanyl Turbohaler(TM) (terbutaline sulfate), according to a mixed factorial design. The different parameters of the equipment (voltage applied to the detector, shear force, deagglomeration, feed rate and pin vibration) were the factors considered in the design, set to different levels. Altogether, a full 4(1) x 3(1) x 2(3) factorial was considered and the results of the experiments analyzed according to the Montgomery technique. Results have shown that samples with a single population of particles were less affected by the changes in the parameters, whereas for mixtures incorporating different populations results were affected upon change of the levels of the factors. The voltage at the detector was the most important factor, followed by the shear force. By contrast, pin vibration and feed rate were less significant. The interactions between variables were also responsible for significant changes in the results and should not be neglected throughout the measurements. (C) 2003 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10451/21252
DOI: http://dx.doi.org/10.1016/j.jaerosei.2003.10.005
ISSN: 0021-8502
Aparece nas colecções:FF - Produção Científica 2000-2009

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