Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21254
Título: Directly compressed mini matrix tablets containing ibuprofen
Preparation and evaluation of sustained release
Autor: Lopes, CM
Lobo, JMS
Costa, P
Pinto, JF
Palavras-chave: Chemistry, Medicinal
Pharmacology & Pharmacy
Data: 2006
Citação: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - Vol. 32, n. 1 (2006), p. 95-106
Resumo: Directly compressed mini tablets were produced containing either hydroxypropylmethylcellulose (HPMC) or ethylcellulose (EC) as release controlling agent. The dynamics of water uptake and erosion degree of polymer were investigated. By changing the polymer concentration, the ibuprofen release was modified. In identical quantities, EC produced a greater sustaining release effect than HPMC. Different grades of viscosity of HPMC did not modify ibuprofen release. For EC formulations, the contribution of diffusion was predominant in the ibuprofen release process. For HPMC preparations, the drug release approached zero-order during a period of 8 h. For comparative purposes, tablets with 10 mm diameter were produced.
URI: http://hdl.handle.net/10451/21254
DOI: http://dx.doi.org/10.1080/03639040500388482
ISSN: 0363-9045
Aparece nas colecções:FF - Produção Científica 2000-2009

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