Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21255
Título: Evaluation of the performance of a new continuous spheronizer
Autor: Pinto, Joao F.
Abreu, Cristina N.
Palavras-chave: Chemistry, Medicinal
Pharmacology & Pharmacy
Data: 2006
Editora: TAYLOR & FRANCIS INC
Citação: DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. - Vol. 32, n. 9 (OCT 2006), p. 1067-1078
Resumo: This study aims to evaluate the performance of a new continuous spheronizer with multiple concentric chambers. The characteristics of the pellets produced in the different chambers (moisture content, mechanical strength, density, sphericity, size, release of a drug) were compared by multivariate analysis of variance (MANOVA), when different times of spheronization and chambers were considered. The statistical analysis has shown that both the diameter of the chambers and the time of spheronization affected the properties of the pellets, and, thus, they must be considered when the spheronizer is used. To minimize these effects all the forming pellets should be processed in all chambers for a defined period of time.
URI: http://hdl.handle.net/10451/21255
DOI: http://dx.doi.org/10.1080/03639040600865231
ISSN: 0363-9045
Aparece nas colecções:FF - Produção Científica 2000-2009

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