Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21256
Título: Compressed mini-tablets as a biphasic delivery system
Autor: Lopes, Carla M.
Lobo, Jose Manuel Sousa
Pinto, Joao F.
Costa, Paulo
Palavras-chave: Pharmacology & Pharmacy
Data: 2006
Editora: ELSEVIER SCIENCE BV
Citação: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - Vol. 323, n. 40210 (OCT 12 2006), p. 93-100
Resumo: Compressed mini-tablets systems are presented as a biphasic delivery system designed for zero-order sustained drug release. The outer layer that fills the void spaces between the mini-tablets was formulated to release the drug in a very short time (fast release), while the mini-tablets provided a prolonged release. Different composition (HPMC or EC) and number (10 or 2 1) of mini-tablets were used to obtain different drug release rates. The in vitro performance of these systems showed the desired biphasic behaviour: the drug contained in the fast releasing phase (powder enrobing the mini-tablets) dissolved within the first 2 min, whereas the drug contained in the mini-tablets was released at different rates, depending up on formulation. Based on the release kinetic parameters calculated, it can be concluded that mini-tablets containing HPMC were particularly suitable approaching to zero-order (constant) release over 8 h time periods. (c) 2006 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/10451/21256
DOI: http://dx.doi.org/10.1016/j.ijpharm.2006.05.063
ISSN: 0378-5173
Aparece nas colecções:FF - Produção Científica 2000-2009

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