Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21265
Título: Catechols from abietic acid
Synthesis and evaluation as bioactive compounds
Autor: Gigante, B
Santos, C
Silva, AM
Curto, MJM
Nascimento, MSJ
Pinto, E
Pedro, M
Cerqueira, F
Pinto, MM
Duarte, MP
Laires, A
Rueff, J
Goncalves, J
Pegado, MI
Valdeira, ML
Palavras-chave: Biochemistry & Molecular Biology
Chemistry, Medicinal
Chemistry, Organic
Data: 2003
Editora: PERGAMON-ELSEVIER SCIENCE LTD
Citação: BIOORGANIC & MEDICINAL CHEMISTRY. - Vol. 11, n. 8 (APR 17 2003), p. 1631-1638
Resumo: Catechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant activity, as well as anticancer and antiviral properties. From all the synthetic catechols tested compound 2 showed the best activities, stronger than carnosic acid. (C) 2003 Elsevier Science Ltd. All rights reserved.
URI: http://hdl.handle.net/10451/21265
DOI: http://dx.doi.org/10.1016/S0968-0896(03)00063-4
ISSN: 0968-0896
Aparece nas colecções:FF - Produção Científica 2000-2009

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