Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21340
Título: Metallo-beta-lactamase VIM-2 in clinical isolates of Pseudomonas aeruginosa from Portugal
Autor: Cardoso, O
Leitao, R
Figueiredo, A
Sousa, JC
Duarte, A
Peixe, LV
Palavras-chave: Infectious Diseases
Microbiology
Pharmacology & Pharmacy
Data: 2002
Editora: MARY ANN LIEBERT INC PUBL
Citação: MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE. - Vol. 8, n. 2 (SUM 2002), p. 93-97
Resumo: Resistance to carbapenems is emerging, and it is a great problem to therapeutics. Three isolates of Pseudomonas aeruginosa from a Portuguese hospital identified in urine and sputum, in 1995, presented a high-level resistance to imipenem (32 mg/L). Afterward, one isolate of P. aeruginosa recovered from urine of an ambulatory patient in 1998 showed high resistance to imipenem. and meropenem. The resistance to carbapenems in these strains was associated with the production of a class B beta-lactamase, as was demonstrated by imipenem hydrolysis and inhibition by EDTA. Using primers described for bla(IMP) and bla(VIM) the amplification of the latter was observed in all isolates and a VIM-2 metallo-enzyme was identified. The pulsed-field gel electrophoresis (PFGE) patterns of these isolates were indistinguishable, suggesting dissemination to the community of this VIM-2 producer.
URI: http://hdl.handle.net/10451/21340
ISSN: 1076-6294
Aparece nas colecções:FF - Produção Científica 2000-2009

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