Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21347
Título: Abietanes from Plectranthus grandidentatus and P-hereroensis against methicillin- and vancomycin-resistant bacteria
Autor: Gaspar-Marques, C
Rijo, P
Simeoes, MF
Duarte, MA
Rodriguez, B
Palavras-chave: Plant Sciences
Chemistry, Medicinal
Pharmacology & Pharmacy
Data: 2006
Editora: ELSEVIER GMBH, URBAN & FISCHER VERLAG
Citação: PHYTOMEDICINE. - Vol. 13, n. 4 (MAR 2006), p. 267-271
Resumo: The antimicrobial activity of 10 natural abietanes isolated from Plectranthus grandidentatus and P. hereroensis acetonic extract was evaluated against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VRE). The results revealed that the most active diterpenes were coleon U (1), 7 alpha-acetoxy-6 beta-hydroxyroyleanone (2) and horminone (3). Minimum inhibitory concentration (MIC) values ranging 0.98-15.63 mu g/ml were obtained for MRSA clinical strains, and MIC values of 15.63 and 31.25 mu g/ml were obtained for VRE clinical strains. Some structure-activity relationships are emphasized. (c) 2005 Elsevier GmbH. All rights reserved.
URI: http://hdl.handle.net/10451/21347
DOI: http://dx.doi.org/10.1016/j.phymed.2005.06.002
ISSN: 0944-7113
Aparece nas colecções:FF - Produção Científica 2000-2009

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