Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21351
Título: Survey of Klebsiella pneumoniae producing extended-spectrum beta-lactamases at a Portuguese hospital
TEM-10 as the endemic enzyme
Autor: Barroso, H
Freitas-Vieira, A
Lito, LM
Cristino, JM
Salgado, MJ
Neto, HF
Sousa, JC
Soveral, G
Moura, T
Duarte, A
Palavras-chave: Infectious Diseases
Pharmacology & Pharmacy
Data: 2000
Citação: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - Vol. 45, n. 5 (MAY 2000), p. 611-616
Resumo: One hundred and thirty-eight isolates of Klebsiella pneumoniae showing resistance to ceftazidime were isolated from different wards of the Hospital de Santa Maria, Lisbon, The genomic DNA of the isolates was analysed by pulsed-field gel electrophoresis (PFGE) and two patterns were predominant. In all isolates the presence of a single large plasmid of about 50 kb suggested that propagation of the outbreak prominently involved plasmid spread, The deduced amino acid sequence indicated the presence of a TEM-10 beta-lactamase. This extended-spectrum P-lactamase was present among K. pneumoniae isolates, was widely disseminated in different wards and remained persistent as a result of an outbreak involving the dissemination of both the multi-resistance plasmids harbouring the bla gene and the isolates themselves.
URI: http://hdl.handle.net/10451/21351
ISSN: 0305-7453
Aparece nas colecções:FF - Produção Científica 2000-2009

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