Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21352
Título: Diversity of chromosomal AmpC beta-lactamases from Enterobacter cloacae isolates in a Portuguese hospital
Autor: Conceicao, T
Faria, N
Lito, L
Cristino, JM
Salgado, MJ
Duarte, A
Palavras-chave: Microbiology
Data: 2004
Citação: FEMS MICROBIOLOGY LETTERS. - Vol. 230, n. 2 (2004), p. 197-202
Resumo: Six clinical isolates of Enterobacter cloacae isolated in a Portuguese hospital, between April 1999 and November 2000, demonstrated resistance to almost all broad-spectrum cephalosporins, except to cefepime. These isolates were susceptible to quinolones and to aminoglycosides. lsoelectric focusing demonstrated production of beta-lactamases with pIs 8.0 and by all six isolates, exhibiting a cephalosporinase phenotype. The results of pulsed field gel electrophoresis revealed that these isolates were genetically unrelated. The amino acid sequence of six AmpC beta-lactamases (EclolFF, Eclo6FF, Eclo9FF, Eclo1OFF, Eclo11FF and Eclol5FF) shared 97-99% homology with the chromosomal AmpC beta-lactamase from E. cloacae P99 and 86-87% homology with those of two plasmid-mediated AmpC beta-lactamases, MIR-1 and ACT-1. This is the first report of chromosomal AmpC beta-lactamase production by E cloacae isolates in a Portuguese hospital. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/10451/21352
DOI: http://dx.doi.org/10.1016/S0378-1097(03)00891-7
ISSN: 0378-1097
Aparece nas colecções:FF - Produção Científica 2000-2009

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