Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21358
Título: 2-(4 '-aminobenzenamine)-pyrimidine, a new alpha-antagonist from Autonoe madeirensis
Autor: Dias, C
Paulo, A
Nascimento, J
Houghton, P
Hawkes, JE
Goncalves, ML
Palavras-chave: Plant Sciences
Chemistry, Medicinal
Pharmacology & Pharmacy
Data: 2003
Editora: GEORG THIEME VERLAG KG
Citação: PLANTA MEDICA. - Vol. 69, n. 11 (NOV 2003), p. 1060-1062
Resumo: A new natural pyrimidine derivative, 2-(4'-aminobenzenamine)pyrimidine (1), was isolated from the bulbs of Autonoe madeirensis, a Hyacinthaceae of the Madeira Archipelago (Portugal) and the structure determined on the basis of spectroscopic data. As some pyrimidine compounds are important alpha(1)-adrenergic antagonists, we investigated the effect of 1 on rat vas deferens contractility induced by the alpha(1)-agonist phenylephrine. In concentrations virtually devoid of effect on the rat vas deferens contractility, 1 shifted to the right the concentration-response curves of phenylephrine without changing the maximal effect. These results provide evidence that 1 acts as an alpha(1)-adrenoceptor antagonist and suggest a competitive mechanism of action.
URI: http://hdl.handle.net/10451/21358
ISSN: 0032-0943
Aparece nas colecções:FF - Produção Científica 2000-2009

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