Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21363
Título: Risk of human exposure to paralytic toxins of algal origin
Autor: Batoreu, MCC
Dias, E
Pereira, P
Franca, S
Palavras-chave: Environmental Sciences
Pharmacology & Pharmacy
Data: 2005
Citação: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. - Vol. 19, n. 3, Sp. Iss. SI (MAY 2005), p. 401-406
Resumo: The most significant neurotoxins produced by harmful algal blooms (HABs) are paralytic shellfish toxins (PSTs) found in shellfish and freshwater. Human exposure to neurotoxins through the food consumption represents a severe hazard to human health and the exposure through contaminated water represents an added risk often difficult to recognize. Furthermore, there is an insufficient knowledge of toxicokinetics of these complex toxins produced by HABs. If human acute exposure occurs, the diagnosis of intoxication is typically based upon symptomatology and analysis of shellfish tissue by mouse bioassay, HPLC-FLD analysis and mouse neuroblastoma assay. However, the health risks due to chronic exposure should also be considered and its prevention could be reached with a better understanding of sub-lethal doses of these toxins. In this context, information required for development of a diagnostic protocol should include knowledge about toxicokinetics and toxicodynamics of these neurotoxins. We emphasise the importance of research on biomarkers to prevent, predict and diagnose acute and chronic human exposure to PST. © 2005 Elsevier B.V. All rights reserved.
URI: http://hdl.handle.net/10451/21363
DOI: http://dx.doi.org/10.1016/j.etap.2004.12.002
ISSN: 1382-6689
Aparece nas colecções:FF - Produção Científica 2000-2009

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