Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21428
Título: Three new jatrophane-type diterpenes from Euphorbia pubescens
Autor: Valente, C
Ferreira, MJU
Abreu, PM
Pedro, M
Cerqueira, F
Nascimento, MSJ
Palavras-chave: Plant Sciences
Chemistry, Medicinal
Pharmacology & Pharmacy
Data: 2003
Citação: PLANTA MEDICA. - Vol. 69, n. 4 (APR 2003), p. 361-366
Resumo: Three new macrocyclic jatrophane diterpene polyesters, named pubescenes A (1), B (2), and C (3), and the known compounds indole-3-aldehyde and scopoletin have been isolated and characterised from the whole dried plant of Euphorbia pubescens. The structures of the new compounds were established by spectroscopic means including 2D-NMR techniques such as COSY, HMQC, HMBC and NOESY experiments. Compounds 1-3 were evaluated for their in vitro effect on the growth of three human cancer cell lines MCF-7 (breast), NCI-H460 (lung) and SF-268 (CNS) as well as for their capacity to interfere with the proliferation of human peripheral blood lymphocytes. They exhibited a moderate growth inhibitory effect on the cancer cell line NCI-H460. No effect was observed on the mitogenic response of human lymphocytes to PHA.
URI: http://hdl.handle.net/10451/21428
ISSN: 0032-0943
Aparece nas colecções:FF - Produção Científica 2000-2009

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