Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21501
Título: Dipeptide vinyl sultams
Synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum
Autor: Valente, Claudia
Guedes, Rita C.
Moreira, Rui
Iley, Jim
Gut, Jiri
Rosenthal, Philip J.
Palavras-chave: Chemistry, Medicinal
Chemistry, Organic
Data: 2006
Editora: PERGAMON-ELSEVIER SCIENCE LTD
Citação: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. - Vol. 16, n. 15 (AUG 1 2006), p. 4115-4119
Resumo: The synthesis of phosphonate derivatives of N-phenyl- and N-benzyl-gamma and delta-sultams, and their application in the Wittig-Horner reaction with N-BOC-L-phenylalanine aldehyde to afford E- and Z-isomers, are described. These compounds were further processed to provide five dipeptide vinyl sultams, which were found to be inactive against papain at concentrations up to 50 mu M. In contrast, vinyl sultams demonstrated weak activity against recombinant falcipain-2 and Plasmodium falciparum W2. (c) 2006 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/10451/21501
DOI: http://dx.doi.org/10.1016/j.bmcl.2006.04.079
ISSN: 0960-894X
Aparece nas colecções:FF - Produção Científica 2000-2009

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