Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21570
Título: Scilla maderensis, TLC screening and positive inotropic effect of bulb extracts
Autor: Dias, C
Graca, JAB
Goncalves, ML
Palavras-chave: Plant Sciences
Chemistry, Medicinal
Integrative & Complementary Medicine
Pharmacology & Pharmacy
Data: 2000
Citação: JOURNAL OF ETHNOPHARMACOLOGY. - Vol. 71, n. 3 (AUG 2000), p. 487-492
Resumo: Scilla maderensis Menezes (Hyacinthaceae) is endemic to the Portuguese Archipelago of Madeira. The taxonomic proximity between Scilla L. and Urigena Steinh. genus, and also the knowledge that bulbs of Urginea maritima (L.) Baker (Scilla maritima L.) contain cardiac glycosides of the bufadienolide type, led us to a phytochemical and pharmacological study of S. maderensis. Extracts obtained from the bulbs were screened by TLC and tested in the isolated frog heart preparation. The TLC screening revealed spots with colours and R-f values similar to those obtained for proscillaridin and scillaren A. In the frog heart preparation the extracts showed a positive inotropic effect and toxic doses induced the arrest of the heartbeat in systole. We can conclude that the bulbs of S. maderensis contain substances exerting pharmacological effects on the heart. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
URI: http://hdl.handle.net/10451/21570
ISSN: 0378-8741
Aparece nas colecções:FF - Produção Científica 2000-2009

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