Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21648
Título: Three new jatrophane polyesters and anti proliferative constituents from Euphorbia tuckeyana
Autor: Duarte, Noelia
Lage, Hermann
Ferreira, Maria-Jose U.
Palavras-chave: Plant Sciences
Chemistry, Medicinal
Pharmacology & Pharmacy
Data: 2008
Citação: PLANTA MEDICA. - Vol. 74, n. 1 (JAN 2008), p. 61-68
Resumo: Three new jatrophane diterpene polyesters named tuckeyanols A and B and euphotuckeyanol, as well as ten known compounds, helioscopinolides A, 13, D and E, naringenin, aromadendrin, coniferaldehyde, 4,20-dideoxy-5-hydroxyphorbol 12,13-diisobutyrate, 4,20-dideoxy-5-hydroxyphorbol 12-benzoate-13-isobutyrate and dehydrodiconiferyl diacetate, were isolated from the methanolic extract of Euphorbia tuckeyana. Their structures were elucidated by physical and spectroscopic methods including 1 D and 2 D homo- and heteronuclear NMR techniques (COSY, HMQC, HMBC and NOESY), and HR-mass spectrometry. Four of the isolated compounds were investigated for their anti proliferative activity in three human gastrointestinal cancer cell lines: gastric (EPG85-257), pancreatic (EPP85-181) and colon (HT-29) carcinomas. Three of them have showed to be moderate inhibitors of the growth of gastric and pancreatic tumor cell lines.
URI: http://hdl.handle.net/10451/21648
DOI: http://dx.doi.org/10.1055/s-2007-993765
ISSN: 0032-0943
Aparece nas colecções:FF - Produção Científica 2000-2009

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