Utilize este identificador para referenciar este registo: http://hdl.handle.net/10451/21649
Título: Antileishmanial activity of piceatannol isolated from Euphorbia lagascae seeds
Autor: Duarte, Noelia
Kayser, Oliver
Abreu, Pedro
Ferreira, Maria-Jose U.
Palavras-chave: Chemistry, Medicinal
Pharmacology & Pharmacy
Data: 2008
Citação: PHYTOTHERAPY RESEARCH. - Vol. 22, n. 4 (APR 2008), p. 455-457
Resumo: In the search for biologically active compounds from Euphorbia lagascae Spreng, an herbaceous plant native to southeast of Iberic Peninsula, a stilbene, two coumarins and two 1-2-deoxyphorbol diterpene esters were isolated by chromatographic methods, from the methanol extracts of its defatted seeds. The structures of these compounds were elucidated by a combination of physical and spectral data (IR, MS and high-resolution H-1-NMR and C-13-NMR spectroscopy utilizing COSY, HMBC, HMQC and NOESY experiments). The stilbene, piceatannol, was screened for its antileishmanial activity against promastigotes as an extracellular form of Leishmania donovani, Leishmania infantum and Leishmania major, and amastigotes of Leishmania donovani as an intracellular form. Pentostan((R)) (sodium stibogluconate), the first line clinical drug, was used as a standard reference. Piceatannol was moderately active against the extracellular forms of the three tested Leishmania species, and more active than the reference compound against the intracellular form of Leishmania donovani. Copyright (c) 2007 John Wiley & Sons, Ltd.
URI: http://hdl.handle.net/10451/21649
DOI: http://dx.doi.org/10.1002/ptr.2334
ISSN: 0951-418X
Aparece nas colecções:FF - Produção Científica 2000-2009

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